Clinical trial

Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

Recruiting now · Not applicable · 1 countries · Registry ID NCT05687188

Recruiting nowNot applicableObservational

What this study is about

This study will evaluate obesity-mediated mechanisms of pancreatic carcinogenesis in minority populations.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersNot accepted

ConditionPancreatic Cancer

Full registry criteria

Inclusion Criteria: * Adults 18 years of age or older at time of signing informed consent * Patients who self-report as African American, Non-Hispanic White * Patients who present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating Florida Pancreas Collaborative (FPC) site or the University of Mississippi Medical Center (UMMC) with a clinical suspicion or diagnosis of a pancreatic tumor. Exclusion Criteria: * Patient under 18 years of age * Has no suspicion or diagnosis of a pancreatic cancer or tumor * Self-reported race/ethnicity other than African American or Non-Hispanic White.

Treatments and study arms

Blood Sample Collection

Other

Participants will have 40 mL of blood drawn at baseline/pre-treatment. The study team will aim to have this blood collected at the time of standard of care blood draw if possible.

Tissue Sample Collection

Other

At the time of tissue biopsy or surgical resection (if applicable) pancreatic tumor tissue, fat, tissue from site of metastasis, and cyst fluid (if applicable) will be collected.

Data Collection

Other

Participants will complete a study questionnaire at baseline that includes medical history, lifestyle, and family history information.

Medical Image Collection

Other

Medical images that are obtained during routine care such as computed tomography (CT) scans, magnetic resonance imaging (MRIs) and ultrasounds will be reviewed by the study team throughout the participant's medical care.

Primary outcomes

Assess molecular and radiological landscape of traditional PDAC tumors in the context of Race/Ethnicityat 36 months

Investigators will compare gene prevalence, type and expression of genetic mutations and radiomic features in African American participants vs Non-Hispanic White participants

Compare biological properties of Adipose Tissue dysfunctionat 36 months

Investigators will compare biological properties of Adipose Tissue dysfunction between African American vs Non-Hispanic White participants.

Examine the role of Adipose Tissue and PDAC tumor interactions in influencing tumor growth, metastasis, and therapeutic responseat 36 months

Investigators will compare the biological interactions of Adipose Tissue and PDAC tumor growth between African American vs. Non-Hispanic White participants to develop new and/or targeted drug combinations.

Study locations

2 locations were listed when this page was built. The first 40 are shown.

University of Mississippi Medical Center🇺🇸 Jackson, Mississippi, United States

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Magdeline D MartinContact

Email · Call 352-672-0548

Shannon Orr, MDPrincipal Investigator

Moffitt Cancer Center🇺🇸 Tampa, Florida, United States

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