Clinical trial

Sympathetic Transduction in Obesity

Opening soon · Not applicable · 0 countries · Registry ID NCT05590546

Opening soonNot applicableObservational

What this study is about

Central (abdominal) obesity is associated with elevated adrenergic activity and arterial blood pressure (BP). Therefore, we tested the hypothesis that transduction of spontaneous muscle sympathetic nerve activity (MSNA) to BP, i.e., sympathetic transduction, is augmented in abdominal obesity (increased waist circumference) and positively related to prevailing BP.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age35 Years to 65 Years

SexAll

Healthy volunteersAccepted

ConditionHypertension

Full registry criteria

Inclusion Criteria: * Nonsmokers * free of metabolic or neurological disease * waist circumference \> 102 cm for men and \> 88 cm for women or waist circumference was \< 94 cm for men and \< 80 cm for women. Exclusion Criteria: * Use of anti-hypertensive medications * history of diabetes * history of smoking within 3 months prior to study participation * hypertension determined by 24-hour ambulatory average BP (\<130/80 mmHg).

Treatments and study arms

No intervention

Other

No intervention, only performing cross-sectional analysis of pooled data collected in previous studies

Primary outcomes

Sympathetic transduction15 min

signal averaging was performed in which bursts of MSNA act as a trigger and beat-to-beat BP was tracked for 15 subsequent cardiac cycles thereafter.

Study locations

0 locations were listed when this page was built. The first 40 are shown.

No public site location was included in this record. Check the original registry for updates.