Clinical trial

Adverse Outcomes and Mortality in Liver Transplant

Recruiting now · Not applicable · 1 countries · Registry ID NCT05477277

Recruiting nowNot applicableInterventional

What this study is about

Prospective natural history pilot study to explore the link between muscle composition using an MRI-based Muscle Assessment Score (MAsS) and adverse outcomes in liver transplant candidates.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersNot accepted

ConditionEnd Stage Liver DIsease, Sarcopenia, Sarcopenic Obesity, Cirrhosis

Full registry criteria

Inclusion Criteria: 1. All patients with end-stage liver disease undergoing evaluation for liver transplantation 2. Patient clinically indicated for MRI during transplant candidacy evaluation 3. Adult Exclusion Criteria: 1\. Contra indication to MRI

Treatments and study arms

MAsS

Diagnostic Test

Add MAsS to standard of care MRI scan

Primary outcomes

Muscle assessment score (MAsS)1 year

The MAsS is a composite score of muscle fat index (% of muscle fat normalized to sex, weight in kg and height in meters) and muscle volume index (muscle volume in liters normalized to patient sex, height in meters and weight in kg)

Adverse outcomes1 year

Number of pre- and post-transplant inpatient days

Adverse outcomes1 year

Number of pre- and post-transplant ICU days

Adverse outcomes1 year

Number of days alive outside of the hospital in the first year after liver transplant

Adverse outcomes1 year

Mortality within the first year after liver transplant

MAsS changes while waiting for liver transplant1 year

In patients who remain on the waitlist, serial MAsS measurements (see Outcome 1) will be taken and changes over time will be assessed

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Mayo Clinic Arizona🇺🇸 Phoenix, Arizona, United States

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Elizabeth Carey, MDContact

Call 480-342-1094