Clinical trial

The Effect of Synbiotic and Diet Modification Among Overweight or Obese Hong Kong Chinese

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT05459909

Active, not recruitingNot applicableInterventional

What this study is about

Synbiotic is a nutritional supplement that contains both prebiotic and probiotic. Probiotics are beneficial microorganisms, while prebiotics are foods that help the growth of beneficial microorganisms in the gut. In the study, dietary intervention with fruits and vegetables and/or synbiotic supplementation with be administered to Hong Kong Chinese subjects for eight weeks. Changes in the composition and diversity of intestinal microbiota, and markers indicative of obesity, chronic inflammation and metabolic dysfunction will be assessed throughout the whole period. This study will further provide a scientific basis for the intake of synbiotics for reducing the risk of overweight and obesity among Hong Kong Chinese. Furthermore, the results will bridge to further research into the most desirable gut microbiome profile, hence facilitating personalised nutrition for optimal health.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age20 Years to 95 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity

Full registry criteria

Inclusion Criteria: * Waist circumference ≥90cm in men and ≥80cm in women * BMI \>23.0kg/m2 Exclusion Criteria: * Practicing dietary restrictions * Using cholesterol-lowering, antihypertensive, anti-inflammatory drugs or Chinese medicines * Consuming laxatives, any gastrointestinal medication, probiotics, prebiotics, synbiotics or antibiotics * Smokers * Alcohol abuser * Currently pregnant or lactating

Treatments and study arms

Synbiotic supplementation

Dietary Supplement

Daily supplementation of synbiotic

Dietary intervention

Behavioral

Increased fruits and vegetables consumption

Primary outcomes

Change in body weight at week 8 compared with baselineWeek 0, 8

Body weight in kilogram

Change in Body Mass Index (BMI) at week 8 compared with baselineWeek 0, 8

BMI = Body weight (in kilograms) divided by square of body height (in meters)

Change in body fat percentage at week 8 compared with baselineWeek 0, 8

Body fat percentage is assessed by bioimpedence

Study locations

1 locations were listed when this page was built. The first 40 are shown.

The Chinese University of Hong Kong🇭🇰 Shatin, Hong Kong

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