Clinical trial

Exercise Training and Fat Metabolism in Postmenopausal Women

Recruiting now · Not applicable · 1 countries · Registry ID NCT05351476

Recruiting nowNot applicableInterventional

What this study is about

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age50 Years to 75 Years

SexFemale

Healthy volunteersNot accepted

ConditionPostmenopausal Symptoms, Obesity, Prediabetic State

Full registry criteria

Inclusion Criteria: * Women * Postmenopausal (50-75 yrs.) * Obese (BMI 30-50 kg/m2) * Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL) * Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week) * Non-smokers * No hormone replacement therapy for at least the past two years. Exclusion Criteria: * Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week) * Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic * Type 1 or type 2 diabetes * Medical problems in which exercise is contraindicated, such as chronic infections * History of, or currently presentation with, cancer, cardiovascular or respiratory disease * Uncontrolled thyroid dysfunction, liver or renal dysfunction * Taking any medication affecting lipid metabolism * Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training * Smokers and those with diagnosed eating disorders

Treatments and study arms

Resistance Exercise

Behavioral

200 Kcal worth of weightlifting, 3 times/week for 12 weeks

Endurance Exercise

Behavioral

200 Kcal worth of treadmill walking, 3 times/week for 12 weeks

Primary outcomes

Change from baseline subcutaneous abdominal adipose tissue glycerol concentration at 12 weeks12 weeks of resistance or endurance training

Changes in physical activity (walking)-stimulated lipolysis will be assessed as measured by glycerol concentration in dialysate samples from subcutaneous abdominal adipose tissue utilizing a powerful in-vivo microdialysis methodology

Change from baseline gluteal adipose tissue glycerol concentration at 12 weeks12 weeks of resistance or endurance training

Changes in physical activity (walking)-stimulated lipolysis will be assessed as measured by glycerol concentration in dialysate samples from gluteal adipose tissue utilizing a powerful in-vivo microdialysis methodology

Change from baseline whole-body lipolysis at 12 weeks12 weeks of resistance or endurance training

Whole body lipolysis will be measured using whole body rate of appearance of 2H5-glycerol in blood samples collected at rest, during walking exercise, and for 120 minutes after exercise.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Florida State University🇺🇸 Tallahassee, Florida, United States

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Michael J Ormsbee, PhDPrincipal Investigator