Clinical trial

Effect of Circadian Rhythm and Physical Exercise in Overweight Type 1 Diabetes Patients

Recruiting now · Not applicable · 1 countries · Registry ID NCT05277532

Recruiting nowNot applicableInterventional

What this study is about

Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in a variety of insulin sensitive organs. The aim of this project is to evaluate, by intervention, the interplay of circadian rhythm and high intensity interval training (HIIT) on glucose control and skeletal muscle metabolism in patients with overweight with or without type 1 diabetes (T1D).

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 50 Years

SexAll

Healthy volunteersAccepted

ConditionType 1 Diabetes, Overweight

Full registry criteria

Inclusion Criteria: * BMI 25-30 * type 1 diabetes or healthy subjects Exclusion Criteria: * nicotine usage, * cardiovascular disease (CVD), * blood pressure \>160/95, * pregnancy, * treatment with other pharmaceutical drugs than insulin, stable dose of thyroid hormone, statins, and antihypertensive drugs (excluding beta blockers). Additional exclusion criteria for diabetes subjects: * diabetes duration less than 6 months, * proliferative or severe non-proliferative retinopathy, * chronic kidney disease with glomerular filtration rate (GFR) \<60 ml/min,

Treatments and study arms

High intensity interval training (HIIT)

Behavioral

HIIT performed either in the morning or in the afternoon

Primary outcomes

Time in Glucose target range (4-10 mmol/L) for tissue glucose from CGM.48 hours

Time in target glucose range (expressed as % of total time) measured by continuous subcutaneous glucose sensors following morning or afternoon HIIT respectively. Measurements are uploaded from the CGM device and analyzed.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Ersta sjukhus🇸🇪 Stockholm, Sweden

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Eva Toft, Assoc ProfContact

Email · Call +4687146500

Veronica Qvist, MD, Ph DContact

Email · Call +4687146500

Ingrid Dahlman, ProfessorPrincipal Investigator