Clinical trial

Twenty-year Follow-up of the Inter99 Cohort

Invitation only · Not applicable · 1 countries · Registry ID NCT05166447

Invitation onlyNot applicableObservational

What this study is about

Being born small increases your risk of developing Type 2 diabetes (T2D) with age. Furthermore, data even suggest that some of the diseases ("complications") in the eyes, kidneys, nerves, liver, blood vessels and heart often seen in T2D patients may not only be due to high blood sugar levels, but rather they to some extent are due to reduced growth in your mother´s womb. The Inter99 cohort included 6784 Danish citizens aged 30 to 60 years when established 20 years ago. Data from the Inter99 cohort showed a strong role of low birth weight (LBW) on T2D risk. The aim is now to reexamine risk of T2D and complications in all the alive 6004 elderly Inter99 participants. Importantly, today there are available techniques to perform detailed examinations for even the earliest signs of complications in both subjects with and without diabetes, and the results of this study will altogether provide important new insights into both the origin and classification of T2D and associated complications. It is hypothesized that being born with lower birth weights increases the adult risk of T2D and heart disease and associated complications in the large and smaller blood vessels.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age50 Years to 82 Years

SexAll

Healthy volunteersNot accepted

ConditionCoronary Heart Disease, Acute Myocardial Infarction, Cardiovascular Diseases, Type 2 Diabetes, Obesity, Birth Weight

Full registry criteria

Inclusion Criteria: * Have participated in the Inter99 Baseline examination. Exclusion Criteria: * Physically or cognitively unable to participate in the 3-hour clinical follow-up study.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Major adverse cardiovascular events (MACE) (Register data)As data are collected from registers, the events are registered as they occur up until 1 Jan 2020.

Composite endpoint of cardiovascular mortality, nonfatal myocardial infarction and nonfatal stroke (3 points MACE). Data are retrieved from the Danish national registers as described in the "study population" section.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Center for Klinisk Forskning og Forebyggelse🇩🇰 Glostrup Municipality, Denmark

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