Clinical trial

Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

Recruiting now · Not applicable · 1 countries · Registry ID NCT05147909

Recruiting nowNot applicableInterventional

What this study is about

Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 80 Years

SexAll

Healthy volunteersAccepted

ConditionPhysical Inactivity, Phosphate Overload, Visceral Obesity

Full registry criteria

Inclusion Criteria: The randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise. Exclusion Criteria: 1. history of cardiopulmonary disease or chronic kidney disease, 2. treatment with antihypertensive medications, 3. estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2, (4) diabetes mellitus or other systemic illness, (5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus \< 2.4 or \> 4.5 mg/dL.

Treatments and study arms

Sodium Phosphate

Dietary Supplement

Sodium Phosphate 2 capsules daily (containing a total of 500 mg of Pi, 372mg of sodium)

Sodium Chloride

Dietary Supplement

Sodium Chloride 2 capsules daily (NaCl, containing a total of 372mg of sodium)

Primary outcomes

oxygen uptake (VO2) during peak exercise4 weeks

VO2 (ml of oxygen consumed /min) will be measured using a metabolic cart (Medgraphics) during exercise in a stationary bicycle. Standard breath-by-breath respiratory gases (VO2) will be measured at rest and after 3 minutes of steady state exercise at both 20 and 40 Watts using a cycle ergometer (Lode). Then, the partcipants will be asked to perform exercise to maximal level to obtain peak VO2.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Texas Southwestern🇺🇸 Dallas, Texas, United States

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John Giacona, PA-CContact