Clinical trial

Risk of Metabolic Adaptation After Weight Loss

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT05139420

Active, not recruitingNot applicableInterventional

What this study is about

This study aims at identifying the neurohormonal biomarkers that characterize individuals at risk of greater metabolic adaptation to weight loss, a disproportionate decline in resting metabolic rate during and after weight loss.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 50 Years

SexAll

Healthy volunteersNot accepted

ConditionWeight Loss, Obesity

Full registry criteria

Inclusion Criteria: BMI \> or = 30 any ethnicity Exclusion Criteria: weight \> or = 400 lbs. diabetes (type 2 or type 1) hypertension heart disease kidney disease liver disease active cancer post solid organ or bone marrow transplant HIV/AIDS pregnancy breastfeeding current smoker current recreational drug use

Treatments and study arms

lifestyle intervention with meal replacement program

Other

participants will be enrolled in a medical weight loss program and will be given a 6 month subscription to a calorie-reduced meal replacement program, in addition to lifestyle advice.

Primary outcomes

change in measured and predicted resting metabolic rate during and after weight loss18 months

resting metabolic rate will be measured by indirect calorimetry every 2 months for 6 months, then every 6 months for an additional 12 month. Predicted resting metabolic rate will be calculated with a mathematical formula at the same time points

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Medical College of Wisconsin🇺🇸 Milwaukee, Wisconsin, United States

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