Clinical trial

Insulin Sensitivity After Breast Cancer

Recruiting now · Not applicable · 1 countries · Registry ID NCT05010356

Recruiting nowNot applicableInterventional

What this study is about

Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes. These metabolic disorders, including insulin resistance, obesity, hyperinsulinemia, and glucose intolerance, are associated with increased BC recurrence and mortality. Skeletal muscle is the major site of glucose uptake in humans. The aims of the present project are to 1) determine the involvement of insulin resistance in skeletal muscle in the metabolic disorders prevalent in BC survivors, 2) identify BC-and/or treatment-induced molecular changes in skeletal muscle from BC survivors .

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age20 Years to 45 Years

SexFemale

Healthy volunteersAccepted

ConditionInsulin Sensitivity/Resistance, Breast Cancer, Survivorship, Metabolic Disturbance

Full registry criteria

Inclusion Criteria: * Premenopausal women operated for breast cancer and after completing adjuvant chemotherapy and no earlier than 3 weeks after its termination * BMI: 25-30 * Healthy controls will be included matched by gender, weight, age, and level of physical activity to the patient group included as subjects Exclusion Criteria: * Known postmenopause occurred at the time of diagnosis of breast cancer * Alcohol intake of\> 7 items / week * Smoker * Already known Type 2 diabetes mellitus or metabolic syndrome and medical treatment thereof. * Cardiovascular disease and its medical treatment * Impaired mobility

Treatments and study arms

Insulin

Drug

Hyperinsulinemic euglycemic clamp

Primary outcomes

Insulin sensitivity status2 years

Glucose infusion rate during the hyperinsulinemic euglycemic clamp to ascertain the insulin sensitivity

Hepatic glucose production2 years

Measurements from the Hyperinsulinemic Euglycemic Clamp will be used to assess insulin effects on hepatic glucose production

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Copenhagen🇩🇰 Copenhagen, DK, Denmark

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Lykke Sylow, PhDContact

Email · Call 0045 20955250