Clinical trial

Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

Recruiting now · Not applicable · 1 countries · Registry ID NCT04791371

Recruiting nowNot applicableInterventional

What this study is about

The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age30 Years to 55 Years

SexAll

Healthy volunteersAccepted

ConditionType 2 Diabetes, Overweight and Obesity

Full registry criteria

Inclusion Criteria: * Sedentary (defined as less than 1 hour per week of physical activity) * BMI: 25-40 * Men and women with and without type 2 diabetes Exclusion Criteria: * Documented cardiovascular disease * Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110 * Obstructive pulmonary disease or asthma * Peripheral neuropathy * Physical impairment that would limit exercise ability * Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD) * Current or past smoking within the last 1 years * Current tobacco use * Anemia * Control HbA1c \> 5.7, T2DM HbA1c \> 9 * Pregnant, nursing or hormonal therapy (other than contraceptives) * Peri or post-menopausal women * Type 1 diabetes * Hepatic or renal disease.

Treatments and study arms

Cardiovascular exercise

Behavioral

15 weeks of cardiovascular exercise 3x/week for 50 minutes/session

Primary outcomes

Change in peak oxygen consumption (VO2)Through study completion, approximately 4 months

Subjects' peak oxygen consumption will be tested on a stationary bike before and after 15 weeks of exercise

Change in insulin sensitivityThrough study completion, approximately 4 months

The investigators will evaluate the changes in insulin sensitivity utilizing a euglycemic insulin clamp

Study locations

2 locations were listed when this page was built. The first 40 are shown.

University of Colorado🇺🇸 Aurora, Colorado, United States

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Benjamin Juckett, MSContact

Email · Call 303-724-1338

Ethan Clark, MSContact

Email · Call 303-724-1354

Judy Regensteiner, PhDPrincipal Investigator

University of Virginia🇺🇸 Charlottesville, Virginia, United States

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Lee Hartline, MEdContact

Email · Call 434-924-5247

Linda Jahn, RNContact

Email · Call 434-924-1134

Zhenqi Liu, MDPrincipal Investigator