Clinical trial
Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity
Active, not recruiting · Not applicable · 1 countries · Registry ID NCT04532814
Active, not recruitingNot applicableInterventional
What this study is about
The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to 55 Years
SexAll
Healthy volunteersAccepted
ConditionUpper Body Obesity
Full registry criteria
Inclusion Criteria: For the exercise studies of leg glucose uptake - "insulin sensitive" group: * Sedentary, normal weight, premenopausal women. * Sedentary, age-matched normal weight men. * Weight stable for two (2) months prior to study. * Willing to provide written, informed consent. * For the exercise studies of leg glucose uptake - "insulin resistant" group: For the exercise studies of leg glucose uptake - "insulin resistant" group: * Upper body obese (UBO) premenopausal women. * Age-matched upper body obese (UBO) men. * Weight stable for two (2) months prior to study. * Willing to provide written, informed consent. Exclusion Criteria: * Age \< 18 or \> 55 years (premenopausal women and age-matched men). * Use of glucose-lowering agents. * For female subjects: positive pregnancy test at the time of enrollment or study * History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy. * Active systemic illness or malignancy. * Symptomatic macrovascular or microvascular disease.
Treatments and study arms
Exercise
Other
Cycling 60% VO2 max
Primary outcomes
Skeletal muscle glucose uptake1 hour
Is exercise induced skeletal muscle glucose uptake different in obese compared to lean adults
Study locations
1 locations were listed when this page was built. The first 40 are shown.
Mayo Clinic in Rochester🇺🇸 Rochester, Minnesota, United States