Active, not recruitingNot applicableObservational
What this study is about
Our goals are to characterize the effects of maternal obesity during pregnancy on infant brain development, reveal the neurodevelopmental consequences, and identify possible mechanisms causing these effects. Our overall hypothesis is that maternal obesity during pregnancy exposes the fetus to an inflammatory environment that affects infant brain structural and functional development and consequently neurodevelopmental outcomes. To test this hypothesis, the investigators will recruit normal-weight and obese pregnant women, examine inflammatory markers associated with obese pregnancy, and correlate them with offspring's brain development evaluated using quantitative MRI methods and outcomes evaluated using neurodevelopmental tests.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to Not listed
SexAll
Healthy volunteersAccepted
ConditionHealthy
Full registry criteria
Inclusion Criteria: * Singleton pregnancy * 11-13 weeks of gestation -≥18 years of age. Exclusion Criteria: * BMI measured at first study visit \<18.5 or between 26-29 or \>50 * hypertension, diabetes, or other preexisting medical conditions known or suspect (by the research team) to influence fetal growth; * family history of psychological or neurogenetic disorders as determined by the research team that may increase the risk of adverse neurodevelopmental outcomes in offspring * medications known to influence fetal growth * recreational drugs, nicotine or tobacco (including smokeless) use or alcohol use while pregnant * medical conditions developed during pregnancy (e.g. gestational diabetes, preeclampsia) known or suspected by the research team to influence fetal growth * infants born preterm (\<37 weeks of gestation), with congenital defects, intrauterine growth restriction, small for gestational age, macrosomia, hypoglycemia, low Apgar score (\<7), or any other medical complications at birth suspected affecting development
Treatments and study arms
The registry does not list a named intervention.
Primary outcomes
To detect changes in brain development by magnetic resonance imaging (MRI)MRIs will be performed on babies at 2 weeks, 1 year, and 2 years.The primary aim is to compare brain development in babies born to lean and obese.mothers by performing MRI scans on babies at 2 weeks, 1 year, and 2 years of life. Mother's BMI will be determined during the clinical visits.
Study locations
1 locations were listed when this page was built. The first 40 are shown.
Arkansas Children's Nutrition Center🇺🇸 Little Rock, Arkansas, United States 