Clinical trial

Exercise, Arterial Modulation and Nutrition in Youth South Africa Study

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT04056377

Active, not recruitingNot applicableObservational

What this study is about

The ExAMIN Youth SA study aims to generate new knowledge on the pathophysiology involved in early vascular aging among South African children and to identify early novel biological markers for predicting the subclinical development of hypertension and target organ damage related to cardiovascular disease. This study further implements state-of-the-art biochemical technology to measure a variety of biological markers including multiplex analyses and metabolomics. With the increasing prevalence of childhood hypertension and obesity, this study will be able to address especially behavioural contributors to hypertension development and to subsequently provide a backdrop for school-based primary prevention interventions.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age62 Months to 129 Months

SexAll

Healthy volunteersAccepted

ConditionHypertension, Retinal Artery Stenosis, Childhood Obesity

Full registry criteria

Inclusion Criteria: * Children between ages 5 and 9 years (both sexes and all ethnicities). Exclusion Criteria: * Children who do not wish to participate or where the parents or caregivers did not provide permission.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

To determine blood pressure classification among primary school children in South AfricaThrough study completion, an average of 1 year

Elevated blood pressure and stage 1 hypertension according to the American Academy of Pediatrics Clinical Practice Guidelines 2017 stratified for age, sex, weight and height. Automated oscillometric calculations of central systolic blood pressure and pulse wave velocity.

To determine overweight and obesity prevalence among primary school children in South AfricaThrough study completion, an average of 1 year

Overweight and obesity classification according to the World Health Organisation percentiles for childhood obesity

To identify novel biomarkers in predicting elevated blood pressure in primary school children from South AfricaThrough study completion, an average of 1 year

Multiplex analysis of cardiovascular and kidney related biomarkers, and subsequently metabolomics and hormone concentrations

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Hypertension in Africa Research Team (HART), North-West University🇿🇦 Potchefstroom, North West, South Africa

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