Clinical trial

Maternal Grandmothers in the Born in Guangzhou Cohort Study

Recruiting now · Not applicable · 1 countries · Registry ID NCT03633162

Recruiting nowNot applicableObservational

What this study is about

The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age36 Years to 100 Years

SexFemale

Healthy volunteersAccepted

ConditionHereditary Transmission, Immune Development, Childhood Obesity, Host and Microbiome, Neurodevelopment

Full registry criteria

Inclusion Criteria: 1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center 2. Baseline information of maternal grandmother's daughter during pregnancy available Exclusion Criteria: 1. Significant cardiovascular abnormalities 2. Intelligent obstacle, intellectual disabilities or gawkish condition

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspringFrom the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth

Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Guangzhou Women and Children's Medical Center🇨🇳 Guangzhou, Guangdong, China

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Xiu Qiu, DoctorContact

Email · Call +862038076001