Clinical trial

DNA Methylation and Vascular Function

Recruiting now · Not applicable · 1 countries · Registry ID NCT03527420

Recruiting nowNot applicableInterventional

What this study is about

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 50 Years

SexAll

Healthy volunteersAccepted

ConditionObesity, Vascular Dysfunction

Full registry criteria

Inclusion Criteria: * BMI ≥ 35 kg/m2 * Between ages 18-50 years * Not pregnant * Approved for a bariatric surgery Exclusion Criteria: * To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded * Pregnant women will be excluded, as they will not be eligible for bariatric surgery * Current smokers * Currently abusing alcohol or drugs

Treatments and study arms

Exercise training

Other

Twelve weeks of aerobic exercise training

Primary outcomes

DNA methylation status of adipocytokines in obese individualsMonth 24-30

DNA methylation of 20 preselected adipocytokines using "Amplicon sequencing-based methylation profiling" will be measured in fat tissue collected from obese individuals who are scheduled for bariatric surgery before and after 12 weeks of aerobic exercise training.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Illinois at Chicago🇺🇸 Chicago, Illinois, United States

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Abeer M Mohamed, MD, PhDContact

Email · Call 312-355-8099