Clinical trial
Bariatric Surgery and Pharmacokinetics of Lamotrigine
Recruiting now · Not applicable · 1 countries · Registry ID NCT03497143
Recruiting nowNot applicableObservational
What this study is about
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on lamotrigine are investigated.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to 70 Years
SexAll
Healthy volunteersNot accepted
ConditionObesity, Morbid
Full registry criteria
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract
Treatments and study arms
Lamotrigine
Drug
Patients are tested for their normal prescription lamotrigine medication
Primary outcomes
Lamotrigine concentration in blood serum (area under curve (AUC))From baseline to 1 year postoperatively
Study locations
1 locations were listed when this page was built. The first 40 are shown.