Clinical trial

Twins Born in Guangzhou

Recruiting now · Not applicable · 1 countries · Registry ID NCT03331133

Recruiting nowNot applicableObservational

What this study is about

The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

AgeNot listed to 18 Years

SexAll

Healthy volunteersAccepted

ConditionTwin Diseases, Immune Development, Childhood Obesity, Host and Microbiome, Neurodevelopment

Full registry criteria

Inclusion Criteria: 1. Live twins delivered in Guangzhou Women and Children's Medical Center 2. Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years 3. Baseline information during pregnancy available

Treatments and study arms

No intervention

Other

Primary outcomes

Neurodevelopment at early childhoodAt age of 1 year old

Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules.

Intelligence quotientAt age of 6 years old

Assessed using the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition including 5 verbal and 3 performance subtests. Intelligence quotient ranges 40-160, in which under 70 is defined as mental retardation. The total score was calculated by an online system.

Change of gene expression during childhoodAge at 1 year , 6 years, 12years and 18years

DNA methylation, histone acetylation etc. assessed by analyses of blood samples

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Guangzhou Women and Children's Medical Center🇨🇳 Guangzhou, Guangdong, China

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Xiu Qiu, PhDContact

Email · Call 0086 20 38367162