Clinical trial

Effects of Blueberry on Gut Microbiota and Metabolic Syndrome

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT03266055

Active, not recruitingNot applicableInterventional

What this study is about

There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health. Whether the beneficial effects of blueberries on obesity and the metabolic syndrome can be linked to their potential impact on the gut microbiota and intestinal integrity remains speculative at this time. Moreover, the mechanisms of action underlying health benefits associated to blueberry consumption are still unknown. The investigators are thus proposing to combine the study of metagenomics, transcriptomics and metabolomics to test whether a prebiotic activity of highbush blueberries can play a role in the prevention of obesity-linked metabolic syndrome in a clinical setting.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 55 Years

SexAll

Healthy volunteersAccepted

ConditionGut Microbiota, Metabolic Syndrome

Full registry criteria

Inclusion Criteria: * Men and premenopause women in good health * Caucasians * At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men * At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L Exclusion Criteria: * Metabolic disorders (hypertension, diabetes, hypercholesterolemia) * Regular use of medication affecting study parameters * Use of natural health product in the last 3 months * Use of antibiotics in the last 3 months * Nicotine users * Allergy or intolerance for blueberries * Blueberry taste aversion * More than 2 alcohol drinks par day * Particular dietary habits (vegetarism, gluten-free diet, cetogenic diet...) * Weight change of more than 5% in the last 3 months * Surgery in the last 3 months or planed during the study

Treatments and study arms

50 g of blueberry powder, taken daily for 8 weeks

Dietary Supplement

Subjects will consume blueberry powder during 8 weeks to test the possible effects of blueberries on gut microbiota composition and on metabolic syndrome parameters.

50g of placebo blueberry powder, taken daily for 8 weeks

Dietary Supplement

Subjects will consume blueberry placebo powder to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and the active treatment (blueberry powder).

Primary outcomes

Changes in plasma insulin/glucose of overweight/obese men and women taking either blueberry powder or placebo blueberry powder12 months

Changes in plasma lipids/lipoproteins of overweight/obese men and women taking either blueberry powder or placebo blueberry powder12 months

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Laval University🇨🇦 Québec, Canada

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