Clinical trial

Guangzhou Nutrition and Health Study (GNHS)

Active, not recruiting · Not applicable · 0 countries · Registry ID NCT03179657

Active, not recruitingNot applicableObservational

What this study is about

Purpose: The Guangzhou Nutrition and Health Study (GNHS) project aims to assess the determinants of metabolic disease in nutritional aspects, as well as other environmental and genetic factors, and explore possible mechanisms with multi-omics integration. Study design: GNHS is a community-based prospective cohort study. Participants: In this cohort, the original GNHS and another cohort study (the controls of a case-control study of hip fractures, CCFH) have been integrated into the one GNHS project. After completing the baseline examination, a total of 5118 participants were recruited during 2008-2015 in the GNHS project. Visits and Data Collection: Participants were/will be visited every three years by invited to the School of Public Health, Sun Yat-sen University. At each visit, face-to-face interviews, specimen collection, anthropometric measurements, dual-energy x-ray absorptiometry (DXA) scanning, ultrasonography evaluation, vascular endothelial function evaluation, cardiopulmonary exercise testing, magnetic resonance imaging (MRI), 14-d real-time continuous glucose monitoring tests, laboratory tests, and multi-omics data were/will be conducted. Up to December 2022, 3442 and 2895 subjects completed the 2nd and 3rd visits. Key variables: 1. Questionnaire interviews. 2. Physical examinations: Anthropometric measurements, blood pressure tests, handgrip strength, muscle function and bracelet motion monitoring. 3. DXA scanning: To determine bone density, bone mineral content, bone geometry information, fat mass, and muscle mass. 4. Ultrasonography evaluations: To determine carotid artery intima-media thickness and plaque, and fatty liver. 5. Vascular endothelial function evaluation. 6. Cardiopulmonary exercise testing: Lung function. 7. MRI: Brain and upper-abdomen MRI. 8. 14-d Real-time continuous glucose monitoring tests. 9. Specimen collections: Overnight fasting blood, early morning first-void urine, faces, and saliva samples. 10. Laboratory tests: Metabolic syndrome-related indices; Diabetes-related indices; Uric acid; Nutritional indices; Inflammatory cytokines; Index of oxidative stress; Adipocytes; Sexual hormones; Liver and renal function-related markers; Routine blood test. 11. Multi-omics data: Genotyping data; Gut microbiota; Untargeted serum and fecal proteomics; Targeted serum and fecal metabolomics. 12. Morbidity and mortality: Relevant data were/will be also retrieved via local multiple health information systems.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age40 Years to 83 Years

SexAll

Healthy volunteersAccepted

ConditionCardiovascular Diseases, Osteoporosis, Diabetes Mellitus, Type 2, Metabolic Syndrome, Obesity, Hypertension, Non-Alcoholic Fatty Liver Disease, Chronic Kidney Diseases, Cancer, Death, Nutrition Disorders, Sarcopenia

Full registry criteria

Inclusion Criteria: * Age: 40-80 years (the original GNHS) and 40-85 years (CCFH) at baseline; * Living in Guangzhou for at least five years; * Chinese. Exclusion Criteria: * Had a history of hospital-confirmed diabetes, failure(s) of heart, liver, or kidney, cancer, cardiovascular events, metabolic bone diseases, glucocorticoid use (over 3 mo.) or sexual hormone use (over 6 mo.), spine or hip fractures; On special diet due to a disease or weight control; * Mental and physical disability; * Likely to move to other city within 5 years; * Did not want to attend any one item of the survey or sample collection.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Cardiovascular diseases (change in carotid artery intima-media thickness, and occurrence of cardiovascular diseases)Up to 15 years

The investigators will track for occurrence of cardiovascular diseases by follow-up surveys and annual record linkage to the population-based disease or death registry collected by the Guangzhou Center for Disease Control and Prevention, and Health Insurance Bureau. All cases will be verified by medical record reviews. The investigators will also measure the carotid artery intima-media thickness at each visit (every 3 years)，and analyze the change of carotid artery intima-media thickness.

Bone health (change of bone mineral density, and occurrence of osteoporosis and fractures)Up to 12 years

The investigators will measure the bone mineral density at each follow-up, and osteoporosis was defined as T-score ≤ -2.5 in accordance with the World Health Organization criteria. The investigators will also track for occurrence of osteoporosis and fractures by follow-up surveys and annual record linkage to the population-based disease or death registration collected by the Guangzhou Center for Disease Control and Prevention, and Health Insurance Bureau. All cases will be verified by medical record reviews. Moreover, the investigators will analysis the annual change of bone mineral density.

Nonalcoholic fatty liver disease (NAFLD)Up to 12 years

The investigators will measure the abdominal ultrasonography at each follow-up and NAFLD was diagnosed based on standard criteria issued by the Fatty Liver Disease Study Group of the Chinese Liver Disease Association. The upper-abdomen MRI was conducted in the 5th visit and NAFLD was diagnosed based on proton density fat fraction. The investigators will also track for occurrence of NAFLD by follow-up surveys and annual record linkage to the population-based disease or death registry collected by the Guangzhou Center for Disease Control and Prevention and Health Insurance Bureau. All cases will be verified by medical record reviews.

Study locations

0 locations were listed when this page was built. The first 40 are shown.

No public site location was included in this record. Check the original registry for updates.