Clinical trial
Taste Physiology in Obese Volunteers Before and After Bariatric Surgery
Recruiting now · Not applicable · 1 countries · Registry ID NCT02902198
Recruiting nowNot applicableInterventional
What this study is about
The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to 55 Years
SexAll
Healthy volunteersNot accepted
ConditionObesity
Full registry criteria
Inclusion Criteria: * morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery * right handed Exclusion Criteria: * cardiovascular disease * neurologic/psychiatric disorders
Treatments and study arms
Placebo
Dietary Supplement
Tap water 200ml
Glucose
Dietary Supplement
25g Glucose in 200ml tap water
Monosodium glutamate
Dietary Supplement
1g monosodium glutamate in 200ml tap water
Quinine
Dietary Supplement
17mg quinine in 200ml tap water
Primary outcomes
Effect of tastants on cerebral blood flow measured by functional brain MRIchanges from baseline to one hour after treatment