Clinical trial

Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

Recruiting now · Not applicable · 1 countries · Registry ID NCT02664831

Recruiting nowNot applicableObservational

What this study is about

This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersAccepted

ConditionCardiac Arrest, Inflammation, Obesity, Hypoxic Ischemic Encephalopathy (HIE)

Full registry criteria

Inclusion Criteria: * Aged 18 years or older * Admitted to the intensive care unit after cardiac arrest episode * Unresponsive after resuscitation Exclusion Criteria: * Moribund / actively dying at the time of evaluation * Informed consent cannot be obtained within 24 hours of resuscitation * Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Correlations between inflammatory markers and clinical outcomes14 days

Correlations between inflammatory markers and clinical outcomes

Correlations between inflammatory markers and biomarkers of neurological and cardiac injury7 days

Correlations between inflammatory markers and biomarkers of neurological and cardiac injury

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Maine Medical Center🇺🇸 Portland, Maine, United States

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David B Seder, MDContact

Email · Call 207-662-2179

Sergey Ryzhov, MD, PhDContact

David J Gagnon, PharmDSub Investigator