Clinical trial

Training Effects on Fuel Metabolism

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT02150889

Active, not recruitingNot applicableInterventional

What this study is about

The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. The investigators are especially interested in learning about the effects of weight and training on insulin resistance. The investigators will study people before and after supervised aerobic or yoga training to identify differences in resting fat and sugar metabolism which may lead to differences in insulin resistance. The investigators will test these differences using stable isotopes, and the use of these stable isotopes is experimental. Overweight/Obese Group: Eight visits will be required at the University of Minnesota Clinical Research Unit. Four visits will be done before training (screen and 3 pre-training visits), 1 visit during the training, and 3 post-training visits will be done. In between, the training will take about 16 weeks and will be a supervised treadmill program. Lean/Trained Group: Four visits will be required at the University of Minnesota Clinical Research Unit (screen and 3 study visits).

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 40 Years

SexAll

Healthy volunteersAccepted

ConditionHealthy Subjects, Lean Trained Subjects, Overweight and Obesity

Full registry criteria

Inclusion Criteria: All subjects 1. Subjects 18 to 40 years of age. 2. Subjects are capable of giving informed consent Overweight or obese 1. Insulin resistant based on screening oral glucose tolerance testing. 2. BMI 25 to 40 kg/m2 inclusive 3. Stable weight for at least 3 months (± 5 lbs.) 4. Sedentary status (self-report \< 30 minutes/week regular exercise). Lean, physically active 1. physically active subjects defined as 3-5 aerobic exercise sessions/week 2. matched to age and gender 3. generally healthy with normal fasting glucose levels (glucose ≤100 mg/dL). Exclusion Criteria: All subjects 1. Subjects 18 to 40 years of age. 2. Subjects are capable of giving informed consent Overweight or obese 1. Insulin resistant based on screening oral glucose tolerance testing. 2. BMI 25 to 40 kg/m2 inclusive 3. Stable weight for at least 3 months (± 5 lbs.) 4. Sedentary status (self-report \< 30 minutes/week regular exercise). Lean, physically active 1. physically active subjects defined as 3-5 aerobic exercise sessions/week 2. matched to age and gender 3. generally healthy with normal fasting glucose levels (glucose ≤100 mg/dL).

Treatments and study arms

Running Program

Behavioral

16 week supervised running program

Yoga Program

Behavioral

once weekly supervised yoga

Primary outcomes

Differences in insulin sensitivity between groupsBefore and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)

Will use HOMA-IR and hyperinsulinemia-euglycemic clamp

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Minnesota🇺🇸 Minneapolis, Minnesota, United States

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