Clinical trial

Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT01623934

Active, not recruitingNot applicableObservational

What this study is about

This study includes 2 phases. During phase 1, pregnant women are followed over the course of pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3, 5 and 10-12 year after delivery. The purpose of this phase 1 is to : * assess the contribution and interactions of adipokines in the development of insulin resistance during pregnancy and gestational diabetes; * assess levels of maternal adipokines as determinants of development and fetal growth; * determine the genetic variations that influence levels of adipokines and glucose regulation during pregnancy and in newborns. The purpose of this phase 2 is to: * identify DNA methylation variations at birth that are predictive of childhood overweight/obesity. * identify maternal characteristics associated with DNA methylation variations predictive of childhood overweight/obesity. * establish whether the loci predictive of childhood overweight/obesity at birth are still differentially methylated at 5 years of age (samples collected at 5 years of age). * identify DNA methylation variations at birth that are predictive of childhood neurodevelopment problems at 3, 5 and 10 years of age.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexFemale

Healthy volunteersNot accepted

ConditionGestational Diabetes, Insulin Resistance, Obesity Prevention

Full registry criteria

Inclusion Criteria: * age ≥ 18 yrs * gestational age between 6 and 13 weeks from last menstrual period * no recognized diabetes or drugs interfering with glucose metabolism * alcohol \< 2 drinks/day * not involved in regular high intensity physical activity * otherwise good health status Exclusion Criteria: * twin pregnancy

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Diagnosis of gestational diabetes mellitus24-28 weeks of gestation

75g oral glucose tolerance test

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Centre de recherche du Centre hospitalier universitaire de Sherbrooke🇨🇦 Sherbrooke, Quebec, Canada

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