Clinical trial

The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism

Recruiting now · Not applicable · 1 countries · Registry ID NCT01477957

Recruiting nowNot applicableObservational

What this study is about

The purpose of this study is: 1. To explore to what extent insulin sensitivity, energy metabolism and ectopic lipid storage can be improved by bariatric surgery 2. To explore to what extent hepatic and muscular disorders of energy metabolism occur in patients with obesity (degree 2-3) 3. To explore whether the steato liver occurring in patients with obesity (degree 2-3) is associated with the degree of liver inflammation

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age20 Years to 70 Years

SexAll

Healthy volunteersAccepted

ConditionObesity, Diabetes Mellitus, Type 2

Full registry criteria

Inclusion Criteria: * Aged ≥ 20 years- ≤ 70 years * BMI 20- 25 kg/m 2 normal- weight group * BMI 35- 39,9 kg/m 2 (Obesity grade 2) * BMI \>40 kg/m 2 (Obesity grade 3) Exclusion Criteria: * Acute illness 2 weeks before start of examination * Autoimmune or Immune disorder diseases (Leukozyten \< 5000/µl * Renal insufficiency (Kreatin \> 1,5 mg/dl) * Heart disease, condition after heart attack * Anemia (Hb \<12g/l, controlled before every day of examination) or blood donations 4weeks before examination. * Participation in another trial within the last 2 weeks * Pharmacological- immunotherapy (Cortisol, Antihistaminika, ASS) * Thyroid disorders * Glitazone Therapy * Pregnancy, Lactation, Menstruation * Smoking cigarettes, Alcohol- and drug abuse * Psychiatric disorders * Risk for/ or diagnosed HIV/ AIDS or Hepatitis B/C * Liver disease, which are not caused by non- alcoholic steato- hepatitis * Working on night shifts or irregular rhythm of night- day * Impaired wound healing or clotting disorders * Allergic reaction to local anesthetics * Malignant cancer

Treatments and study arms

surgery

Procedure

biliopancreatic diversion, gastric banding, gastric sleeve resection

Primary outcomes

Energy metabolism5 years

whole body substrate oxidation, ex vivo mitochondrial function via measurement of high resolution respirometry and in vivo mitochondrial function via measurement of ATP production

Study locations

1 locations were listed when this page was built. The first 40 are shown.

German Diabetes Center🇩🇪 Düsseldorf, North Rhine-Westphalia, Germany

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Michael Roden, Prof., MDContact

Email · Call 0049211-3382

Sabine Kahl, MDContact

Email · Call 0049211-3382