Clinical trial

Study of Changes in Skeletal Muscle After Caloric Restriction

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT00993460

Active, not recruitingNot applicableObservational

What this study is about

Research has shown that fat stored within muscles affects the muscle's sensitivity to insulin and ability to handle blood glucose. The purpose of this study is to examine the effects of weight loss surgery-induced caloric restriction on the accumulation and types of fats within skeletal muscle, as well as the effects of such caloric restriction on insulin sensitivity and inflammatory responses in skeletal muscle. The investigator proposes that caloric restriction will result in decreases in diacylglycerols enriched with saturated fat and increases in diacylglycerols enriched with monounsaturated fats.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age21 Years to 65 Years

SexFemale

Healthy volunteersAccepted

ConditionObesity

Full registry criteria

Inclusion Criteria: * For Normal Weight Subjects: * Age 21-65 years * BMI of 21 to 27 kg/m2 * Normal glucose tolerance as determined by OGTT on day of screening * No family history of diabetes * For Morbidly Obese Subjects: * Age 21-65 years * BMI of 30 to 65 kg/m2 * Scheduled for Roux-en-Y gastric bypass at Vanderbilt Medical Center * Insulin resistant as determined by OGTT on day of screening Exclusion Criteria (for all subjects): * Clinically significant heart disease * Clinically significant hepatic or renal disease * Pregnancy * Breastfeeding * Any abnormality that would preclude safe completion of study * Use of statins * Use of thiazide or furosemide diuretics, beta blockers, or other chronic medications with known adverse effects on glucose tolerance levels unless subject has been on stable dose of such medications for the past 3 months before entering the study

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Diacylglycerol content and compositionafter 10% body weight loss

Muscle lipid will be analyzed by LC-MS/MS

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Vanderbilt University Medical Center🇺🇸 Nashville, Tennessee, United States

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