Clinical trial

Dietary, Physiological, Genetic, and Behavioral Predictors of Health in a Young, Ethnically-Mixed Population

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT00945633

Active, not recruitingNot applicableObservational

What this study is about

Dietary intervention and other strategies to prevent unhealthy weight gain and the development of obesity should be based on knowledge of dietary, physiological, genetic and behavioral determinants and their contributing interactions. Identifying these determinants is difficult because physiological susceptibility to specific dietary and behavioral factors implicated in unhealthy weight gain differs between populations and individuals within the populations. The research challenge is identifying specific determinants in a free-living, adult population. Understanding the interaction between diet and the underlying susceptibility factors such as physiologic, genetic and epigenetic, and behavioral factors mandate an integrated approach. This integrated approach should include understanding the interplay of physiological factors (genetics, epigenetics, taste preferences, susceptibility to energy excess, etc.) and behavioral factors (food cravings, restraint, disinhibition, physical activity) as each of these domains is a potential driving force in energy expenditure, food preference, dietary choices, and food intake. Which of these factor(s) is most important? The investigators propose that by examining dietary, physiological, genetic, and behavioral factors in an integrated fashion we will gain insight into the obesity epidemic and identify the most important determinants of weight gain. As a secondary aim, the investigators will identify a single parsimonious collection of factors and develop strategies to mitigate the risks of developing obesity.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age20 Years to 35 Years

SexAll

Healthy volunteersAccepted

ConditionObesity

Full registry criteria

Inclusion Criteria: * Inclusion criteria will be healthy men and women between the ages of 20-35, with BMI \< 27.5 kg/m2, and fasting blood glucose \< 126 mg/dl. Exclusion Criteria: * History of diabetes, history of obesity (BMI \> 30). * History of known inherited medical conditions that might influence future health status. * Current or planned medication usage that might influence future health status. * Prior serious injuries/surgeries that might influence future health status. * Women who are pregnant or breastfeeding (once enrolled, pregnancy will not cause subjects to be terminated from the study). * Women who are \< 6 months postpartal, or women who have discontinued breastfeeding \< 3 months prior to screening. * History of cancer (including skin cancer) within 5 years. * History or organ transplant. * Previous diagnosis with HIV, Hepatitis B or C, or tuberculosis. * Abuse of alcohol or illegal drugs. * Abnormal EKG. * Presence of pacemaker, defibrillator, or implanted metal. * History of eating disorders and abnormal psychological scores for the screening measures described under Psychological Assessment Measures in the Appendix. This psychological screening will be conducted approximately two weeks prior to outpatient testing.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Changes in body weightAnnually over 2 years

Changes in body weight (kg) from baseline

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Pennington Biomedical Research Center🇺🇸 Baton Rouge, Louisiana, United States

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